"My cards were dealt differently," Isis, a 22-year-old former receptionist, tells Us Weekly exclusively in its new issue, on newsstands now.
Hailing from Prince George's County, Maryland, Isis identifies herself as "a woman born physically male."
Will she be a role model?
"I like to help people, but I'm here to follow my dreams," she tells Us.
The inclusion of Isis is being hailed by GLAAD president Neil Giuliano as "an unprecedented opportunity for a community that is underrepresented on television.
"We applaud Tyra Banks and The CW for making this historic visibility of transgender people possible," Giuliano said.
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